10 results
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
micro-damage exceeds ability ... StressFractures #msk ... #orthopedics #pathophysiology
Antiplatelet Drugs and their Actions

- Amy Chung, MD, MSc
@AmyChung

#Antiplatelet #Medications #Pharmacology #Pathophysiology #Drugs #Agents #COX #GIIbIIIa
Amy Chung, MD, MSc ... #Medications #Pharmacology ... #Pathophysiology
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Amy Chung, MD, MSc ... #Medications #Pharmacology ... #Pathophysiology
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings

Pars interarticularis stress fracture (spondylolysis) - most frequently in the
S1 => Weakened stability ... Spondylolisthesis #MSK ... #diagnosis #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Complications: • Inability ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology
Isolated Anterior Cruciate Ligament (ACL) Injury: Pathogenesis and clinical findings
 • Feeling a "pop"
 • Acute
deep in knee • Instability ... giving out" • Inability ... few weeks but instability ... #ACL #Injury #MSK ... #Sports #pathophysiology
One and a Half Syndrome on Physical Exam

This 28 year old patient presented to clinic with
maintained the ability ... diagnosed with MS ... clinical #video #ophthalmology
Presbyopia: Pathogenesis and clinical findings
 • Presbyopia is part of the normal ageing of the lens
lens -> Decreased ability ... • Decreased ability ... contract -> Decreased ability ... #Presbyopia #pathophysiology ... #ophthalmology
Checkpoint inhibitors and indications
Anti CTLA-4 antibody:
 • Ipilimumab: Malignant melanoma, Renal cell cancer
Anti-PD-1 antibody:
 • Nivolumab:
microsatellite instability ... (MSI-High), Esophageal ... microsatellite instability ... (MSI-High), Renal ... indications #oncology #pharmacology
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
fracture site more stability ... fracture-site stability ... #Orthopedics #msk ... #Staging #pathophysiology