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management differential idsa opportunistic prevention abscess anemia aplastic cytomegalovirus emergencies hematology hemophagocytic hlh immune inflammatory iris ltbi lung lymphohistiocytosis mycobacterium
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
↑ sIL-2R >2400 Ul ... +: Virus (EBV, CMV ... or biologics (CMV ... immune deficiency, Drugs ... , Unknown cause
IDSA Recommendations for Treating Cytomegalovirus Infections in HIV-AIDS Preventing CMV Disease: • CMV end-organ disease is best
Cytomegalovirus Infections ... intraocular levels of drug ... control of the infection ... until steady state ... #HIVAIDS #pharmacology
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
polymicrobial infection ... • Most common cause ... once stable - ... Cavitation > 6 cm ... shows a small, stable
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - β-lactam antibiotics ... - EBV - CMV ... aplastic anemia Treatment ... oncology #hematology #diagnosis
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
• A state of hyperinflammatory ... superinfection, drug ... keratitis, iritis • CMV ... unintentional weight loss, nausea ... /drug resistance
Orthopedic Emergencies Compartment Syndrome • An increase in compartment pressure to the point where tissue perfusion is
incisions, 15 cm ... Syndrome • Syndrome caused ... progressive inflammatory infection ... • Diagnosis: ... - Antibiotic
IDSA Recommendations for Treating Mycobacterium Tuberculosis Infection and Disease in HIV-AIDS Treating LTBI (to prevent TB disease) Indications:
Mycobacterium Tuberculosis Infection ... a person with infectious ... and molecular diagnostic ... Please refer to the table ... #HIVAIDS #pharmacology
Causes of Myoclonus - Differential Diagnosis LOCALIZATION: • Cortical: Focal/multifocal: Distal UL+ Face, Action/sensitive induced • Sub-Cortical:
Causes of Myoclonus ... Axial/Bilateral, Startle ... trauma • Acute: Infections ... opioids, psychiatric drugs ... , AED, antibiotics
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