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management diagnosis idsa opportunistic prevention differential antibiotics mycobacterium abscess anemia aplastic aviumcomplex capsulatum classification cytomegalovirus diarrhea hematology hemophagocytic histoplasma histoplasmosis
Important causes of diarrhea in people with HIV/AIDS Severity, chronicity/persistence will depend On CD4 count & sites
count & sites of infection ... 1) Bacteria: ... 2) Viral: - CMV ... insufficiency, drug-induced ... #Diarrhea #HIVAIDS
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
↑ sIL-2R >2400 Ul ... +: Virus (EBV, CMV ... , HHV8,...), Bacteria ... or biologics (CMV ... immune deficiency, Drugs
IDSA Recommendations for Treating Cytomegalovirus Infections in HIV-AIDS Preventing CMV Disease: • CMV end-organ disease is best
Cytomegalovirus Infections ... intraocular levels of drug ... control of the infection ... until steady state ... #HIVAIDS #pharmacology
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
polymicrobial infection ... • Most common cause ... antibiotics once stable ... Cavitation > 6 cm ... shows a small, stable
Antibiotic classification refers to the categorization of antibiotics based on their chemical structure, mechanism of action,
Antibiotics are drugs ... treat bacterial infections ... Imagine treatments ... #Antibiotics #pharmacology ... classification #table
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - Cytotoxic drugs ... - EBV - CMV ... Cytomegalovirus (CMV ... aplastic anemia Treatment
Sulfonamides - Antibiotics Class Overview BACTRIM/SEPTRA (TMP/SMX) - inhibit sequential steps in Folate synthesis --> bacteriostatic Spectrum: Wide
Class Overview BACTRIM ... Notable highlights ... including PCP PNA (drug ... choice, both for treatment ... #Pharmacology #Antibiotics
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
• A state of hyperinflammatory ... superinfection, drug ... keratitis, iritis • CMV ... unintentional weight loss, nausea ... /drug resistance
IDSA Recommendations for Treating Mycobacterium Tuberculosis Infection and Disease in HIV-AIDS Treating LTBI (to prevent TB disease) Indications:
Mycobacterium Tuberculosis Infection ... a person with infectious ... Please refer to the table ... opportunistic #infections ... #HIVAIDS #pharmacology
IDSA Recommendations for Preventing and Treating Disseminated Mycobacterium Avium Complex in HIV-AIDS Preventing 1st Episode of Disseminated
necessary based on drug-drug ... please refer to Table ... IDSA #Prevention #Treatment ... opportunistic #infections ... #HIVAIDS #pharmacology
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