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diagnosis disease hematology hemophagocytic hlh lymphohistiocytosis adultonset aosd adult anesthesiology bacilliformis bartonella causes differential fungal hemeonc hyperthermia infections infectiousdiseases macrophage
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Clinical triad: Fever ... #AdultOnset #Stills ... Disease #diagnosis #management ... #treatment #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... : High spiking fever ... Disease #AOSD #rheumatology ... #diagnosis #management ... #treatment
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
Treatment depends ... Actively maintained fever ... Anesthesiology #Anesthesia ... #Checklist #Diagnosis ... #Management #Workup
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... • Adult-onset Still ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... • Clinical: fever ... +, Adult-onset Still ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... and cytokine storm ... following: • Fever ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Treatment - Mild ... : NSAIDS Treatment ... AOSD #diagnosis #rheumatology ... #management
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... , malaise, chills ... coinfection, toxo reactivation ... TREATMENT: ​• Acute ... #diagnosis #management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... , cough, chills, ... pulmonary symptoms • Rheumatologic ... • Isolated fever ... Fungal #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... by uncontrolled activation ... • Cytokine storm ... Fever b. ... #Hematology #HemeOnc
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