10 results
Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
Evaluation and ... Management #Diagnosis ... #Management #Hematology ... Manifestations #Workup ... #Algorithm #Ddxof
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... : - ANA > ... Positive in 60-80% of cases ... • Evolution:
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... : - ANA > ... Discontinuation of causal ... : - ANA > ... #diagnosis #management
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... in drug-induced SLE ... Polyangiitis (Churg-Strauss ... Jcortesizaguirr #ANA
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA, ... #algorithm #rheumatology
Serious Bacterial Illness (SBI):
1) UTI and pyelonephritis
Most common cause of SBI
Accounts for 3-8% of uncharacterized fevers
Female
pyelonephritis Most common cause ... Consider BCx, CSF evaluation ... suggested if: - ANC ... #Peds #EM #Classification ... SeriousBacterialIllness #Ddxof
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Workup History ... function test, ANA ... (e.g., SLE), anti-phospholipid ... - Bone marrow evaluation ... #Causes #Workup
Algorithm for the Evaluation of Kawasaki and Incomplete Kawasaki Disease:
Diagnosis
* Fever >5d
* Criteria (4/5)
  -
Evaluation of Kawasaki ... and Incomplete ... #Peds #Pediatrics ... Disease #Criteria #Workup ... #Algorithm #Ddxof
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
- Differential Diagnosis ... Disease: Discoid lupus ... Scarring Alopecia: Lupus ... • Laboratory evaluation ... DHEAS) • ANA
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
• Immunologic Workup ... : - ANA > ... Discontinuation of causal ... #DIL #rheumatology ... #diagnosis #treatment