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hematology management oncology differential rash algorithm erythematosus leukemia lupus smear systemic thrombocytopenia activation acute agglutinin agitation aplastic babesia babesiosis bancrofti
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... • Tumor lysis syndrome ... -> Invade Skin: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Autoimmune • ITP • SLE ... • CLL • APLA ... Non-lmmune: • HELLP Syndrome ... Algorithm #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Orange or Hep C Clinical ... Hepatomegaly • Skin ... • Neutropenia, anemia ... workup #oncology #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... - Hemolytic anemia ... Associated - SLE ... #hematology #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Sjögrens (15%) Skin ... Demyelinating syndromes ... ) Blood (75%): Anemia ... #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (anemia) ... Pinpoint-sized red spots ... just beneath the skin ... • Aplastic Anemia ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Clinical Presentation ... Headaches • Pale skin ... #oncology #hematology ... #diagnosis #management
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... Differential Diagnosis ... • Goodpasture syndrome ... #rash #diagnosis ... #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... • Symptoms of anemia ... anemia • Cold ... #hematology #diagnosis
Vibrio Vulnificus skin infection Cirrhosis w/recent consumption of raw oysters w/rapidly evolving rash. Vibrio vulnificus part of
cellulitis w/ black spots ... hemochromatosis, hemolytic anemia ... rash #cellulitis #dermatology ... #legs #clinical ... #photo
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