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diagnosis differential algorithm causes potassium low metabolic bartter management urine bulimianervosa chloride complications defects diabetes diabetic dka endocrinology fanconi hhs
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... Metabolic alkalosis ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome • Urine Chloride • Urine Ca/Cr ratio Dr. Krithika
syndrome from Bartter ... syndrome • Urine ... #syndrome #Bartter ... #Algorithm #nephrology ... #hypokalemia #diagnosis
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... syndrome - Mutation ... • Bartter syndrome ... #nephrology #management ... #pathophysiology
Localization of Renal Tubular Defects Fanconi Syndrome: Proximal tubule Bartter Syndrome: Thick ascending loop of Henle Gitelman Syndrome: Distal
Defects Fanconi Syndrome ... tubule Bartter Syndrome ... Syndrome: Distal ... Nephron #Defects #Pathophysiology ... #Nephrology
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Aldosterone: Liddle's Syndrome ... SAME, Cushing Syndrome ... diuretics, Bartter syndrome ... , Gitelman syndrom ... potassium #low #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm Volume Depleted 2° hyperaldosteronism • Low Urine Cl-: Vomiting, NGT
Diuretics, Bartter Syndrome ... , Gitelman Syndrome ... GRA, Cushing's syndrome ... , Liddle syndrome ... Diagnosis #Algorithm #nephrology
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift: • Alkalosis ... • G-CSF • Hypokalemic ... • Refeeding syndrome ... Diagnosis #Algorithm #nephrology
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
↓ Aldosterone: Syndrome ... excess, Liddle's syndrome ... - Metabolic Alkalosis ... Diuretics, Bartter syndrome ... , Gitelman syndrome
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm Volume Depleted - 2° hyperaldosteronism • Low Urine Cl-: Vomiting,
Diuretics, Bartter Syndrome ... , Gitelman Syndrome ... GRA, Cushing's syndrome ... , Liddle syndrome ... Diagnosis #Algorithm #Nephrology
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts: - Alkalosis ... diuresis, Bartter's syndrome ... diuretic use), Gitelman's ... syndrome (mimics ... excess and related syndromes
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