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hematology differential algorithm generalized leukemia management mds myelodysplastic pruritus secondary systemic workup alopecia anemia chronic cll disorders hair hairloss loss
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... old, ~10,000 new cases ... Myelodysplastic #Syndrome ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... • Improve the symptoms ... #Anemia #oncology ... #hematology #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... K), H. pylori test ... (GI symptoms/endemic ... ), (neurologic/psychiatric ... #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... Liver Function Tests ... Myelodisplastic syndrome ... Psychiatric Disease ... #generalized #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... with no early symptoms ... Pure red cell aplasia ... #workup #oncology ... #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
development of skin symptoms ... Causes: - Idiopathic ... Leukemia cutis Diagnosis ... #diagnosis #dermatology ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... age 70 years Symptoms ... • Anemia • Aplastic ... #diagnosis #hematology ... #oncology
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
- Differential Diagnosis ... Alopecia mucinosa, Aplasia ... , Loose anagen syndrome ... disease • Pull test ... #dermatology #Hairloss
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Liver Function Tests ... Myelodisplastic syndrome ... Psychiatric Disease ... #generalized #dermatology ... #Algorithm #causes
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