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diagnosis differential hepatology laboratory transaminitis function hematology interpretation lactate management product reactions tests acidosis algorithm arthritis bloodsmear borrelia causes chemistry
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Tests (LFTs) - ... Hepatopathy • Acute ... injury) • Ischemic ... Function #Tests #LFTs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Mixed - Check Acute ... injury < 26 weeks ... intestines, White blood ... transaminitis #LFTs
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... brain, heart, blood ... hepatocellular injury ... Function #Tests #LFTs
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... > 20x normal - Acute ... #Patterns #Liver ... #LFTs #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Liver Injury: ... Liver Injury: ... Liver Injury: ... intestines, white blood
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
RBCs, muscle, liver ... deficiency of red blood ... : • Early acute ... hepatitis • Acute ... Hepatocellular Injury
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
removal from the blood ... or renal injury ... cardiac output - Acute ... peritonitis - Acute ... Injury: • Reduced
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... - Acute Hemolytic ... Transfusion Related Acute ... Lung Injury (TRALI ... eruptions, diarrhea, liver
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... • Acute Hemolytic ... Transfusion Related Acute ... Lung Injury (TRALI ... eruptions, diarrhea, liver
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
on Peripheral Blood ... Mild LFT ↑ This ... Specific organ injury ... smear, acute and ... often experience acute
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