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Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
lymphocytes/Mature B cell ... Orange or Hep C Clinical ... smear: Smudge cells ... or basket cells ... and other C Cell
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
Airway epithelial cells ... promote dendritic cell ... These T cells then ... induce B-cell class ... induce goblet cell
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Pathogenesis and Clinical ... Natural Killer Cells ... • Humoral: (B cell ... : (T cell response ... and cytotoxic cell
Sickle cells
These photos show sickle cells on peripheral blood smears. In the left photo target cells
Sickle cells These ... photos show sickle cells ... photo, target cells ... clinically and ... #Clinical #Path
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Involvement - B-cell ... CD10 - T-cell ... or λ), Smudge Cells ... - B-cell ... Thrombocytosis - T-cell
Cellular and humoral immune responses of the adaptive immune system. Activated T cells accomplish cellular immune
Activated T cells ... responses, and B cells ... antigen activates B cells ... binding to the B-cell ... binding to the T-cell
Schistocytes can assume a shape resembling natural or man-made objects such as arrowheads, fish, collar buttons,
point to helmet cells ... are a teardrop cell ... , 2 blister cells ... ), and 2 burr cells ... #Clinical #Path
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
of ALL is of B-cell ... lymphadenopathy • Blast cells ... organs When Cancer Cells ... Hypogammaglobulinemia, smudge cells ... form of large cell
B/T Cell Development
This is a work in progress describing the maturation of B & T cells
B/T Cell Development ... maturation of B & T cells ... more to the T cells ... #lymph node #b-cell ... #t-cell
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antibodies bind to mast cells ... activation and cell ... with cytotoxic T cells ... natural killer cells ... - Red blood cell