11 results
Direct-acting oral anticoagulants (DOACs) for VTE treatment and prevention - Comparison Table

#DOAC #Anticoagulants #Anticoagulation #VTE #Management
anticoagulants (DOACs ... ) for VTE treatment ... prevention - Comparison Table ... #DOAC #Anticoagulants ... Anticoagulation #VTE
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... anticoagulants (DOACs ... body mass index; VTE ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
effect prior to surgery ... interruption per treatment ... table ... Low Bleed-Risk Surgery ... Perioperative #Management #Treatment
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
for VTE in Malignancy ... risk of recurrent VTE ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
thromboembolism (VTE ... Provoked (e.g. surgery ... - No other workup ... - Recurrent VTE ... Hypercoagulable #Workup
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... ) Cancer-treatment ... DOACs are substrates ... Chemotherapy #Oncology #Hematology ... #Interactions #Table
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... surgery or urgent ... anticoagulant treatment ... not available #DOAC ... anticoagulant #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... life-threatening • Treatment ... sle #comparison #table ... #rheumatology #
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia
• Unexplained hypotension
• Unexplained bronchospasm (wheeze may be absent
non-essential surgery ... trolley, anaphylaxis treatment ... require prolonged treatment ... as patient is stable ... Diagnosis #Management #Workup
Peripartum Cardiomyopathy - Summary
1. Definition
 • Towards the end of pregnancy to 5 months postpartum
Avoid Warfarin and DOAC ... during Delivery • Stable ... Serial TTE and close ... management #cardiology #treatment