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Epidemiological Clues That May be Helpful in Defining the Etiological Diagnosis of Culture-Negative Endocarditis

#Endocarditis #Bacteria #Differential
Epidemiological Clues ... Etiological Diagnosis of Culture-Negative ... #Endocarditis #Bacteria ... #Differential # ... Microorganisms #Clues
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
My Patient with Infective ... Endocarditis (IE ... therapy - Number one cause ... of culture negative ... #Diagnosis #Management
Primary and Secondary Causes of Mitral Regurgitation
Primary (organic) chronic mitral regurgitation:
 • Leaflet: Rheumatic fever, Infective
), Spontaneous rupture ... infarction, Tendineae rupture ... Papillary muscle rupture ... Regurgitation #differential ... #diagnosis #cardiology
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
culture negative ... infective endocarditis ... identified with modern culture ... #differential # ... #culture #negative
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... identified with modern culture ... - Standard culture ... #Infective #Endocarditis
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Culture (+): ... • Coagulase-negative ... staphylococci Culture ... #diagnosis #management ... #cardiology
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
and Differential ... Culture Positive ... staphylococci Culture ... • Persistent bacteremia ... Diagnosis #cardiology
Causes of Primary and Functional Mitral Regurgitation (MR) 
Causes of primary mitral regurgitation
 - Rheumatic heart
mitral stenosis - Infective ... /marantic endocarditis ... MV chordae may rupture ... laterally from myocardial ... #Diagnosis #Cardiology
Peripartum Cardiomyopathy - Summary
1. Definition
 • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... Differential Diagnosis ... heart disease • Myocardial ... recommend against future ... • During a future