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diagnosis differential clinical hepatology management algorithm pocus causes pathophysiology ultrasound pharmacology hematology radiology hepatic treatment photo gastroenterology nejm physicalexam cirrhosis
Functions of the Liver Storage Degradation Metabolism Synthesis #Pathophysiology #Functions #Liver #Hepatology #Synthesis #Storage #Metabolism
Functions of the Liver ... Metabolism Synthesis ... Pathophysiology #Functions #Liver ... #Hepatology #Synthesis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... In liver, 80% of ... phosphatase: • Synthesis ... due to increased synthesis ... clearance - AP synthesis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Identify Acute Liver ... - Specific to liver ... salts augment synthesis ... ALP - Due to synthesis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Causes of Acute Liver ... artery: Shock liver ... salts augment synthesis ... ALP - Due to synthesis
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Findings in Hepatic / Liver ... Decreased albumin synthesis ... fold with acute liver ... hepatocytes; in chronic liver ... has exhausted liver
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone: • Liver ... expression/protein synthesis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Decreased factor synthesis ... • Reduced liver ... synthesis (impaired
Calcium homeostasis is a process controlled by chiefly by hormones vitamin D and PTH. Vitamin D
circulation via synthesis ... processes in the liver
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Decreased factor synthesis ... Reduced liver synthesis
Bile acids are the end products of cholesterol catabolism. Cholic acid and chenodeoxycholic acid are the
synthesized in human livers ... Human liver synthesizes ... circulation to liver ... replenished by de novo synthesis ... in the liver to
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