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Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
ALP enzyme- Discovered ... in 1923 Low ALP ... 1948 by Rathbun ALP ... synthesized in: ... Neuropathy ALP
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
/ULN ALT) / (Alk ... specificity to elevated ALP ... • AST/ALT > ALP ... GGT/5-NT: ↑ • ALP ... hemolysis) • ALP
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
or AST > ALP): ... • Severe - ALT ... • Moderate - ALT ... Cholestatic Pattern (ALP ... > ALT or AST):
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
kidney, brain ALT ... for the liver ALP ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP)
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
specificity to elevated ALP ... • AST/ALT > ALP ... GGT/5-NT: ↑ - ALP ... disease - If ALP ... hemolysis) • ALP
Pathways Involved in Protein and Amino Acid Metabolism in Chronic Kidney Disease. The tricarboxylic acid (TCA)
Urea is synthesized
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Injury • AST/ALT ... elevation > Alk ... phos • ALT more ... • R value = (ALT ... + ULN ALT) / (alkaline
Lipoprotein Metabolism Enterocytes release absorbed lipids the form of triglyceride-rich chylomicrons. These are acted upon by endothelial
cholesterol to synthesize
Bile acids are the end products of cholesterol catabolism. Cholic acid and chenodeoxycholic acid are the
primary bile acids synthesized ... Human liver synthesizes
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Chemistry Tests - AST, ALT ... Metabolism AST and ALT ... cytoplasmic (CAST) • ALT ... clearance - AP ... bile canaliculi (ATP-dependent
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