TAK diagnosis neurology syndrome causes hematology table rheumatology algorithm management comparison eosinophils eosinophilia hypereosinophilia

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Hypereosinophilia and Hypereosinophilic Syndrome

• Secondary Hypereosinophilic Syndrome
• Clinically Relevant HES Variants
• When to

disorders • Diagnosis ... and Treatment Algorithm ... #Hematology #eosinophilia ... #eosinophils #diagnosis ... #management #algorithm

Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and

: An absolute eosinophil ... Secondary Causes ... #eosinophilia #diagnosis ... #hematology #differential ... #management #eosinophils

Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
• Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or

Eosinophil Disorders ... Peripheral blood eosinophilia ... of eosinophilia ... #Differential #diagnosis ... #hematology #eosinophilia

Causes of Eosinophilia - Differential Diagnosis
Bugs:
- Fungus (aspergillosis)
- Viral (HIV)
- Ectoparasites (scabies, myiasis)

Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Syndrome - Chronic ... Eosinophilic Leukemia ... #Causes #hematology

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition:
• Severe adverse drug reaction, characterized by

Reaction with Eosinophilia ... lymphadenopathy, eosinophilia ... Eosinophilia 4 ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis

Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes

decades of life Causes ... neutrophils and eosinophils ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table

Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years

What?
• Aplastic anemia

Constitutional Syndromes ... and petechiae Causes ... - Hepatitis, eosinophilic ... Anemia #oncology #hematology ... #diagnosis #management

Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,

affects the skin, neurologic ... progressive) EGPA (Eosinophilic ... Polyangiitis): • Eosinophilia ... tract, and often causes ... #Rheumatology

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