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differential rheumatology management algorithm ana anca antibody antineutrophil antinuclear arterial classification embolism glomerulonephritis knee msk physicalexam progressive prs pulmonary rapidly
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
Causes of Knee Effusions ... - Differential Diagnosis ... fracture - Patellar dislocation ... Osteosarcoma - Eosinophils ... #diagnosis #msk
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ANCA-Associated Vasculitis ... ANCA+ 60% • Eosinophilic ... Renal-limited vasculitis ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Purpura Anti-GBM antibodies ... involvement: Anti-GBM Disease ... #differential #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... • EGPA: - Eosinophilia ... tract, and often causes ... C-ANCA) pattern: antibodies ... #rheumatology #
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... life-threatening diseases ... EGPA) • Auto-antibodies ... LVEF, pericardial effusion ... Goodpasture's cause
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... Antiphospholipid antibodies ... 19 - PNH - Vasculitis ... Venous #Arterial #pathophysiology ... #hematology #differential
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... thickening or effusion ... ) • Cutaneous vasculitis ... Nephrogenic DI Hematologic ... : 2% Systemic Vasculitis
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