TSH dermatology skinrash algorithm anemia workup oncology hemolytic hemolysis anemias intravascular disease key differential agglutinin cold platelets extravascular causes

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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Causes Intravascular ... anemia): ... agglutin disease ... #Hemolytic #Intravascular ... #Causes #differential

Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
-

Causes of Extravascular ... and Intravascular ... Hemolysis - Differential ... anemia • ... #Algorithm #Causes

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

• Symptoms of anemia ... Diagnosis: • hemolytic ... anemia • Cold ... the RBCs causing intravascular ... #hemolytic #anemia

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... agglutinins disease ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential ... #workup #hematology

Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
• Enzyme deficiencies ex. G6PD, pyruvate kinase
• Hemoglobinopathies

for Hemolytic Anemia ... : • Liver disease ... IVIG infusion Intravascular ... udaygulati #Hemolytic ... #Anemia #Differential

TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A

hemorrhage and hemolysis ... result in severe anemia ... reflection of intravascular ... hemolysis Platelet ... anemia Indirect

Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It

Weight loss • Anemia ... nodosum • Immune hemolytic ... anemia • Pain ... Hodgkin Lymphoma Workup ... #oncology #management

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