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differential hyponatremia causes management gitelman cardiology chf clinical criticalcare foamed heartfailure hypotonic icu low neurology pharmacology physiologic sarcoidosis signs symptoms
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... #Pathophysiology ... #nephrology #diagnosis
Hyponatremia - Differential Diagnosis Algorithm Hypovolemic - Give volume Hypervolemic (Edematous) - Look for and treat underlying cause
cirrhosis, nephrotic syndrome ... Potomania - Tea ... Stress, Nausea, Pulmonary ... #Algorithm #diagnosis ... #nephrology #sodium
Modified Hyponatremia Algorithm Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants Hypotonic Hyponatremia: • ADH ON (UOsm > 100):
Modified Hyponatremia Algorithm ... ON (UNa < 30): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... #diagnosis #sodium ... #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
- Differential Diagnosis ... Algorithm Syndrome ... • Drugs • Pulmonary ... Malignancy True hypovolemia ... #Hyponatremia #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
- Differential Diagnosis ... Algorithm Syndrome ... • Drugs • Pulmonary ... Malignancy True hypovolemia ... #Hyponatremia #Nephrology
Hyponatremia - Differential Diagnosis by Mechanism Decr Blood Pressure (“Decr Effective Circulating Volume”) - Volume depletion
- Cirrhosis Syndrome ... hemorrhage) - Pulmonary ... potomania - “Tea ... #Table #Causes ... #Sodium
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... Cirrhosis, Nephrotic syndrome ... #differential #diagnosis ... #table #sodium ... #nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Inherited (AR) hypokalemic ... thiazide-sensitive sodium ... thiazide-sensitive sodium ... #diagnosis #nephrology ... #management #pathophysiology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... survival is 93-95% Pathophysiology ... Self-limiting, chronic but stable ... Pulmonary: dyspnea ... acute sarcoidosis Pulmonary
Hyponatremia - Differential Algorithm Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP Hypotonic Hyponatremia: • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
- Differential Algorithm ... Hyponatremia: • Hypovolemia ... Cirrhosis, Nephrotic Syndrome ... #diagnosis #causes ... #nephrology #sodium
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