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management hematology differential syndromes amiodarone anemia aplastic apml arthritis bronchiectasis cancer chronic cll differentiation emergencies fungal hemeonc hepatology hepatopulmonary induced
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... : >3 symptoms, or ... #oncology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... Renal Syndromes ... or serologies + symptoms ... sparing of the lung ... #management #treatment
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... → no immediate treatment ... renal failure, pulmonary ... #Emergencies #Oncology ... #HemeOnc #Diagnosis
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... absence of intrinsic lung ... on radioactive lung ... resolution of symptoms ... #treatment #hepatology
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
inflammation Symptoms ... • Mounier-Kuhn syndrome ... in the adjacent lung ... of the affected lung ... mycobacteria Treatment
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
acute respiratory symptoms ... symptoms • Rheumatologic ... symptoms • Pericarditis ... change in the lungs ... nails, bronchi, lungs
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... aplastic anemia Treatment ... • Improve the symptoms ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... microglobulin Treatment ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
starting amiodarone treatment ... respiratory distress syndrome ... gradually with symptoms ... Improvement in symptoms ... macrophages Treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... factor (GCSF) treatments ... marrow studies Treatment ... #diagnosis #hematology ... #oncology
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