147 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilic Syndrome ... • Secondary ... suspect underlying hematologic ... Diagnosis and Treatment ... #HES #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... K), H. pylori test ... thyroid function test ... , ANA (e.g., SLE ... #Workup #hematology
Causes of Secondary Hypertension - Differential Diagnosis and Screening Testing
Common causes: 
 • Renal parenchymal disease
Causes of Secondary ... • Cushing’s syndrome ... Mineralocorticoid excess syndromes ... Acromegaly #Secondary ... #Screening #Workup
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
leakage of RBC's secondary ... Splenomegaly - CTD (SLE ... Kasabach-Merritt syndrome ... Associated - SLE ... Differential #Diagnosis #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... autoantibodies that will cause ... APS), Secondary ... Erythematosus #SLE
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... • Screen for secondary ... (common causes ... glucocorticoid treatment ... Differential #diagnosis #hematology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Initial screening test ... block • Sjogren syndrome ... polymyositis overlap syndrome ... severe disease Treatment ... Summary #diagnosis #rheumatology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Algorithm and Causes ... #Differential #Causes ... #Workup #Hematology ... GrepMed Recommended Text
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... Differential Diagnosis Secondary ... Myelodysplastic syndrome ... Differential #Diagnosis #Causes ... #hematology #secondary
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... constitutional symptoms • Treatment ... Discontinuation of causal ... • Immunologic Workup ... life-threatening • Treatment