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diagnosis hematology differential anemia algorithm causes clinical hemolytic blood hemolysis smear bloodsmear classification interpretation mcv path rbc atlas dermatology electrophoresis
Thalassemias on Hemoglobin Electrophoresis Beta-Thalassemia: • Major • Intermediate • Trait Alpha Thalassemia: • Trait-1 (α α/ α-)
Thalassemias on ... Electrophoresis Beta-Thalassemia ... • Trait Alpha Thalassemia ... DeLoughery @Bloodman #Thalassemias
Thalassemia - Electrophoresis - Comparison Table In this disorder it is the defective production of hemoglobin that
Thalassemia - Electrophoresis ... types are the beta-thalassemia ... , alpha-thalassemia ... @Bloodman #Thalassemias
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia, Thalassemia ... Target cells - Thalassemia ... elliptocytosis, Thalassemia ... anemia, Sickle-thalassemia
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
G6PD deficiency, Thalassemia ... Basophilic stippling: Thalassemia
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Pappenheimer Bodies: Thalassemia ... Lead poisoning, Thalassemia
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
deficiency • Thalassemia ... : Alpha thalassemia ... , Beta thalassemia
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
HgbA • Beta-Thalassemia ... HgbA • Beta-Thalassemia ... • Alpha-Thalassemia
Pathophysiology of Hemolytic Anemia - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects) -
internal contents (thalassemia
Anemia - Hemolysis Diagnostic Algorithm Autoimmune hemolytic anemia Microangiopathic hemolytic anemia Probable thalassemia Dr. Eric Strong @DrEricStrong - Strong Medicine
anemia Probable thalassemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Pyridoxine deficiency, Thalassemia ... Target Cell RBC: Thalassemia ... disease, S-beta thalassemia
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