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hepatology algorithm lfts transaminitis management aflp chemistry common dermatology distribution drug druginduced fatty function gastroenterology hepatitis idiosyncratic induced interpretation obgyn
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... #differential # ... Diagnosis #Management ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis ... disorder (e.g. ascites ... #Injury #Diagnosis ... #Algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... Diagnosis Framework ... (>1000): • DILI ... injury) • Ischemic ... #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... #differential # ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
disease: > 2 • NASH ... Unconjugated Bili ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
develops (DIC, ascites ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... Diagnosis: Viral ... #Pregnancy #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... normal - Hemolysis, NASH ... #Injury #hepatology ... transaminitis #differential ... #diagnosis
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
pustules, to crusted sites ... site of previous injury ... ; pruritis #dermatology ... #rash #differential ... #diagnosis #skin
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