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differential management antibodies activation ana anemia antinuclear autoantibodies causes erythematosus hemolytic leukemia lupus macrophage mas myopathy myositis oncology patterns sjogrens
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... methotrexate) • Drugs Autoimmune ... • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... #Hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Associations ANA ... , autoimmune hepatitis ... microsomal) - Autoimmune ... #diseases #diagnosis ... #table #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... Thyroid, Autoimmune ... ANA #patterns #rheumatology ... #diagnosis #differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... genotypes): SS, SC, SE ... Schistocytes, thrombocytopenia ... elliptocytosis, autoimmune ... #hematology #testing
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Non-autoimmune ... rheumatologic diseases ... disorders (e.g. thyroid ... #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(MAS) Classified ... erythematosus [SLE ... leukopenia, anemia, and thrombocytopenia ... #Diagnosis #Management ... #Hematology #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... and peripheral Thyroid ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... #Rheumatology #
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
mesothelioma, etc - Autoimmune ... erythematosus (SLE ... cell lymphoma Pathophysiology ... Histopathological Diagnoses ... #management #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... ALL: mediastinal mass ... infiltrates (anemia, thrombocytopenia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... Consider infectious, thyroid ... RP-ILD), dermato-rheumatologic ... (also seen in association ... Myositis #Myopathy #rheumatology
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