13 results
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... : High spiking fever ... maculopapular rash ... : high fever, CRP ... #management #treatment
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... maculopapular skin ... #Adult #onset ... Stills #disease #AOSD ... #management
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic ... instability - New-onset ... fever with rash ... sulfa-drug - Skin ... #Dermatology #Rash
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Clinical triad: Fever ... Arthralgia/arthritis, Skin ... rash ± odynophagia ... #management #treatment
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
arthritis (sJIA) • Adult-onset ... - Nonremitting fever ... Petechial or purpuric rash ... erythematosus [SLE], AOSD ... #Diagnosis #Management
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
+ sudden onset ... of a rash - Rash ... general feeling of ill ... - Sudden onset ... #diagnosis #dermatology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
rash in association ... Fever >38.5 2. ... withdrawal • Mild ... SinaiBmoreIMRes #DRESS #Syndrome ... #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... cytokines (TNFa,lL1, IL6 ... • Clinical: fever ... diseases: SLE+++, Adult-onset ... #management #treatment
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... 3rd Decade Skin ... Differential Diagnosis ... rheumatoid arthritis, adult-onset ... to: Arthritis, Fever
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
and Management ... 4) Average age onset ... survival is 93-95% Pathophysiology ... nodes: 13-15%, skin ... #Management #Signs