14 results
management dermatology differential disease hematology hemophagocytic hlh lymphohistiocytosis stills syndrome adult adultonset algorithm antimda5 antimda5dm aosd autoimmune causes color comparison
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
: - Fever >= 39C ... weeks - Typical skin ... rash: maculopapular ... #Diagnosis #Major ... #Minor #Rheumatology
Maculopapular - Diagnostic Algorithm Pathophysiology: - Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic ... instability - New-onset fever ... with rash - Mucocutaneous ... sulfa-drug - Skin ... #Dermatology #Rash
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
with urticarial rash ... Rash: • Nonpruritic ... - Yamaguchi criteria ... maculopapular skin ... #rheumatology #
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... • Rheumatic fever ... gangrenosum • IBD ... #differential #diagnosis ... #rheumatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
blood donor • Pathophysiology ... sequestration and activation ... explain symptoms • Fever ... pulmonary edema) • Fever ... #diagnosis #comparison
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Petechial or purpuric rash ... Histopathologic criteria ... #Syndrome #Diagnosis ... #Rheumatology
Kawasaki Disease: Clinical Findings Diagnostic Criteria - Fever and 4/5 of the following: • Conjunctivitis • Polymorphous
Clinical Findings Diagnostic ... Criteria - Fever ... • Polymorphous rash ... - Generalized Skin ... #Diagnosis #Pathophysiology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... Dermatomyositis • Fever ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... IFN-y) → Excessive activation ... • Clinical: fever ... treatment #summary #rheumatology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
rash in association ... Criteria for Diagnosis ... Fever >38.5 2. ... Skin involvement ... withdrawal • Mild
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