11 results
Acute Purpura Fulminans Skin Rash on Physical Exam 
60 year old male ITP s/p splenectomy 
1d
Skin Rash on Physical ... Exam 60 year old ... Your blood cxs identify ... BIDMC Infectious Diseases ... #photo
Pigmented Purpuric Dermatoses (PPD) - Capillaritis

Group of chronic, benign, cutaneous eruptions characterized by the presence of
extremities Schamberg Disease ... Extravasation of blood ... which allow red blood ... brown tint of the rash ... eczematous features • Mild
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... • Adult-onset Still ... (Petechial or purpuric ... rash) • Heart, ... Syndrome #Diagnosis #Management
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Disease Systemic ... maculopapular skin ... #Adult #onset #Stills ... #rheumatology #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... IFN-y) → Excessive activation ... Phagocytosis of blood ... +, Adult-onset Still ... Lymphohistiocytosis #diagnosis #management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... arthritis, adult-onset Still ... CNS • Headache, mild ... Seizures • Strokes Skin ... Chronic B-cell activation
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
the extent of disease ... • Periorbital purpura ... Inflammation → Macrophage activation ... waxy or thickened skin ... Diagnostic Testing Blood
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
maculopapular rash ... Post Transfusion Purpura ... Causes purpura & ... infections with skin ... Transfusions #diagnosis #management
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... Post Transfusion Purpura ... Causes purpura & ... infections with skin ... Transfusion #diagnosis #management
PALM RASHES 
Common features and patterns:
1.	Color:
o	Red or erythematous: Common in inflammatory or allergic reactions.
o	Purple or purpuric:
o Purple or purpuric ... such as small blood ... occur in chronic skin ... , or bullous skin ... Fungal Infections (Tinea