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differential dermatology dermatomyositis antimda5 antimda5dm antinxp2 antinxp2dm autoimmune biphasic cns encephalitis erythema heat heatstroke infections leptospirosis management meningitis myopathy myositis
SKIN RASHES Skin rashes can occur from a variety of factors, including infections, heat, allergens, immune
SKIN RASHES ... rapid and accurate diagnosis ... fever and systemic signs ... of illness should ... petechiae; #purpura; #rash
Biphasic Illness of Leptospirosis Some patients do not progress to severe disease. Others, rapidly develop severe disease
• Pretibial maculopapular ... rash • Others ... : nausea, vomiting ... Biphasic #Phases #Diagnosis ... #Illness #Signs
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... chest (in a V-sign ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
- Differential Diagnosis ... fatigue Heat Rash ... blisters on the skin ... → Syncope • Signs ... #causes #stroke
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... Episcleritis Signs ... Causes: - Idiopathic ... influenza-like illness
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
pharyngitis • Maculopapular ... rash • Cough ... Acute meningeal signs ... second phase of the illness ... • Uveitis • Rash
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... , mucositis • Rash ... tract, and often causes ... vesicles, pustules, maculopapular ... #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... Muscle atrophy may cause ... Dermatomyositis: • ILD ... #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... ) • Shawl sign ... statins - probably caused
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