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Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
(GPA) Skin involvement ... Maculopapular rash ... macules • Erythematous ... • Goodpasture syndrome ... #rash #diagnosis
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Joint Pain Rash ... infection Malar rash ... Sarcoidosis • GPA ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
• Microscopic Polyangiitis ... > PR3 60% • GPA ... : erythematous nodules ... mucositis - Rash ... erythematosus,
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Skin ulcers ... - GPA, EGPA, microscopic ... polyangiitis ... (e.g. systemic lupus ... erythematosus (
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... Antiribosomal P, APLA, PAC ... Seizures • Strokes Skin
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
: Erythematous nodules ... , mucositis • Rash ... MPO > PR3 60/ GPA ... • Behcet syndrome ... • Cogan syndrome
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... Demyelinating syndromes ... SLE #systemic #erythematosus
Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE)

49M +burning rash groins/buttocks (pic in next thread) x 1d.
groins/buttocks (pic ... well-demarcated, erythematous ... known as baboon syndrome ... , blisters, or purpura ... #clinical #photo