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diagnosis rheumatology differential classification dermatology sle cryoglobulinemia cryoglobulins dermatitis dermatologic erythema granulomatosis hematology joint monoclonal oncology pain palm paraproteinemias polyangiitis
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Sarcoidosis • GPA ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
> PR3 60% • GPA ... : erythematous nodules ... mucositis - Rash ... lupus erythematosus ... • ANCA (Dx: GPA
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Maculopapular rash ... macules • Erythematous ... • Ulcerated, erythematous ... • Goodpasture syndrome ... #dermatology #rash
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... Demyelinating syndromes ... #erythematosus #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... - Skin ulcers ... reticularis & skin ... - GPA, EGPA, microscopic ... lupus erythematosus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... lupus erythematosus ... Seizures • Strokes Skin ... #Lupus #Erythematosus
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: Erythematous nodules ... , mucositis • Rash ... MPO > PR3 60/ GPA ... • Behcet syndrome ... • Cogan syndrome
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... Autoimmunity: • -MM/WM: Vasculitis ... WAIHA • CAD • PCH ... to cold IgG • Lupus
PALM RASHES Common features and patterns: 1. Color: o Red or erythematous: Common in inflammatory or allergic reactions. o Purple or purpuric:
Color: o Red or erythematous ... o Purple or purpuric ... inflammation (vasculitis ... occur in chronic skin ... Fungal Infections (Tinea
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