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diagnosis rheumatology differential signs symptoms vasculitis classification erythematosus joint management activation algorithm arthropathies arthropathy behcet cryoglobulinemia cryoglobulins dermatology disease disorders
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Sjögrens (15%) Skin ... , Vasculitis, Purpura ... Demyelinating syndromes ... #SLE #systemic
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Henoch Schönlein purpura ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
arthritis - (Reiter’s syndrome ... arthritis - with the skin ... Lupus - with Systemic ... (SLE), should have ... like “butterfly rash
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Antiribosomal P, APLA, PAC ... Seizures • Strokes Skin ... #Systemic #Lupus
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
biliary cirrhosis (PBC ... ), or with systemic ... lupus erythematosus ... (SLE) Signs / ... Xeroderma (Dry skin
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... (Petechial or purpuric ... rash) • Heart, ... lupus erythematosus ... [SLE], AOSD) •
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... - Skin ulcers ... reticularis & skin ... lupus erythematosus ... (SLE), rheumatoid
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... mucositis - Rash ... • Cogan Syndrome ... lupus erythematosus ... vasculitis, and SLE
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Mucocutaneous lymph node syndrome ... , mucositis • Rash ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... lesions, palpable purpura ... response to local skin ... Oral aphthae : SLE ... • Arthritis: SLE
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