10 results
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
Antifungal Azoles ... - Antibiotics Class ... hepatic, main toxicity ... Isavuconazole(PO or IV) #Pharmacology ... #Antibiotics #Review
Utilization of Antibiotics as Antidotes

Valproic Acid Toxicity:
Carbapenems 

Amatoxin Mushrooms: 
Polymyxin B, Penicillin, Cyclosporine

Infographic by Mike O'Brien
@MikeEMPharmD

#Antibiotics
Utilization of Antibiotics ... Valproic Acid Toxicity ... MikeEMPharmD #Antibiotics ... #Antidotes #Toxicology ... #Pharmacology
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
Flutycosine - Antibiotics ... Thrombocytopenia) and Hepatic toxicity ... monitored to reduce toxicity ... #Pharmacology #Antibiotics ... #Flutycosine #Antifungal
Hydroxychloroquine and Chloroquine in COVID19

Dosing:
Hydroxychloroquine:
 - 400mg PO BID on the first day, followed by 200mg
Chloroquine in COVID19 ... agent (increased toxicity ... #Chloroquine #COVID19 ... #HCQ #Pharmacology ... #Management #Medications
Common Medications Known to Prolong QTc
Antiarrhythmics - Amiodarone, sotalol, flecainide, quinidine, dronedarone, dofetilide
Vasopressors/inotropes - Epinephrine, norepinephrine,
Common Medications ... , venlafaxine Antibiotics ... promethazine Antifungals ... #Prolongation #Medications ... differential #diagnosis #pharmacology
Reported Mechanisms and Toxicity of Investigational Treatments for SARS-COV-2
Chloroquine and Hydroxychloroquine
 • Mechanisms: Interference with ligand
Mechanisms and Toxicity ... 3 response • Toxicity ... combined with certain medications ... #Toxicology #Medications ... #SARSCOV2 #COVID19
The 8 A’s — drugs that interact with warfarin
Antibiotics 
 - Most agents, but especially co-trimoxazole,
with warfarin Antibiotics ... - Rifampin Antifungals ... Mnemonic #8As #Pharmacology ... #Medications
Hydroxychloroquine is an antimalarial & DMARD (disease modifying antirheumatic drug). It is currently being discussed as
treatment for COVID ... (increased BB toxicity ... COVID-19 NOTE: be ... who require this medication ... Hydroxychloroquine #HCQ #Pharmacology
Drug-Induced Prolonged QTc

QTc >500ms is an independent risk factor for developing Torsades des Pointes (TdP)
Drugs causing
Risperidone • Antibiotics ... Prolonged #QTc #Toxicity ... #Toxicology #Pharmacology
Digoxin Pharmacology and Monitoring

 • Digoxin’s half-life is 30-45 hours in healthy adults
 • When monitoring
Digoxin Pharmacology ... More important indications ... Kat_Watson #Digoxin #Pharmacology ... #Monitoring #toxicology ... #management #toxicity