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diagnosis liver transaminitis algorithm biliary pbc primary abnormal apml causes chemistry cholangitis differentiation function hematology hepatitis interpretation liverenzymes liverfunctiontests management
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Tests (LFTs) - ... • NAFLD • Cirrhosis ... Drug-induced liver injury ... Diagnosis #hepatology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary Cirrhosis ... Smoking, Microbial triggers ... T-cell mediated BEC injury ... Primary #Biliary #Cirrhosis ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... CMV), Alcoholic cirrhosis ... Patterns #Liver #Injury ... #hepatology #LFTs ... transaminitis #differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... #Elevated #Abnormal ... Algorithm #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... specificity to elevated ... hepatitis: < 1 • Cirrhosis ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... normal or slightly elevated ... Normal early on but elevated ... bile ducts Differential ... diagnosis #workup #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... specificity to elevated ... hepatitis: < 1 • Cirrhosis ... #hepatitis #differential ... diagnosis #algorithm #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
the study) • Triggers ... ATRA treatment Pathophysiology ... if WBC > 5 or elevated ... initiation • Differential ... diagnosis #management #hematology
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