13 results
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Smoking, Microbial triggers ... DNA methylation Genetic ... relative with PBC ... T-cell mediated BEC injury ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Diagnosis Algorithm ... stone, Malignancy, PBC ... Tests of synthetic function ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
of Acute Liver Injury ... - Differential ... Diagnosis Hepatocellular ... Malignancy, 1° PBC ... Acute #algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Diagnosis Framework ... 500-1000): • Genetic ... Drug-induced liver injury ... #Diagnosis #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Diagnosis Algorithm ... - CBD stone, Biliary ... #hepatology #LiverFunctionTests
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... hepatocellular injury ... , genetic (?) ... Interpretation #diagnosis ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Pathophysiology ... Diagnosis: • ... bile ducts Differential ... #workup #hepatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
the study) • Triggers ... ATRA treatment Pathophysiology ... initiation • Differential ... Diagnosis: Infection ... #management #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Marrow (Toxic injury ... specific loss-of-function ... Syndromes: - Genetic ... Anemia #oncology #hematology ... #diagnosis #management
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... include extrahepatic biliary ... body mass index; FBC ... Abnormal #Algorithm #Hepatology ... Liver #Enzymes #Differential