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diagnosis liver lfts syndrome transaminitis aflp algorithm apml biliary causes differentiation encephalopathy fatty function hematology hepatitis neurology obgyn obstetrics oncology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary Cirrhosis ... Smoking, Microbial triggers ... T-cell mediated BEC injury ... Primary #Biliary #Cirrhosis ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... • NAFLD • Cirrhosis ... : • Genetic/Metabolic ... Drug-induced liver injury ... #Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... CMV), Alcoholic cirrhosis ... NASH, Genetic / Metabolic ... #hepatology #LFTs ... transaminitis #differential
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Rhabdomyolysis - Differential ... Diagnosis and Management ... syndrome, Electrical injury ... , Heat stroke, Metabolic ... Dermatomyositis) AKI - Pathophysiology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... infiltration) Differential ... Liver #Pregnancy #hepatology ... #pathophysiology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Shock liver • Metabolic ... hepatitis: < 1 • Cirrhosis ... #hepatitis #differential ... diagnosis #algorithm #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
the study) • Triggers ... ATRA treatment Pathophysiology ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... Reversible course Differential ... Drug toxicity, Metabolic ... Seizures: Treat with AEDs ... Syndrome #diagnosis #management
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