47 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... the study) • Triggers ... ATRA treatment Pathophysiology ... #management #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... • Triggers: Diuretics ... WBC >100k, + lab signs ... : • Pathophysiology ... #management #hematology
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... , AML, NHL → AKI ... #TumorLysis #syndrome ... #TLS #Pathophysiology
Problem Representation - Approach to the Infectious Disease Patient

Who: Patient age and host/risk factors (such as
factors (such as ... illness What: Key signs ... define the clinical syndrome ... febrilepodcast@gmail.com #InfectiousDiseases
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... but can also spontaneously ... and AML) and solid ... #Tumor #Lysis #Syndrome ... #management #UricAcid
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Cauda Equina Syndrome ... lumbar spine Signs ... • As soon as ... #CaudaEquina #Syndrome ... #MSK #pathophysiology
Antiphospholipid Syndrome (APS)
APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid Syndrome ... (APS) APS is a ... Antiphospholipid antibodies (aPL ... Antiphospholipid #Syndrome ... #management #anticoagulation
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Pathophysiology ... tendency to fall • Triggers ... superimposed spasms triggered ... SPS #Diagnosis #Management
Emphysematous Cystitis
Epidemiology:
 • Usually middle-aged diabetic women
 • Other RF: neurogenic bladder, urinary tract outlet obstruction,
compromise Clinical Signs ... be present or signs ... Pathophysiology: ... Coli, but can also ... Urine cultures also
Management of Serotonin Syndrome
Identify and stop all serotoninergic medications
 • Avoid inadvertent Rx of serotoninergic meds
Management of Serotonin ... Syndrome Identify ... and stop all serotoninergic ... normalize vital signs ... #Management #treatment