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diagnosis differential hematology neurology apml cerebritis differentiation disease erythematosus fungal infections leukostasis lupus lysis mycoses myelitis oncology sle symptoms systemic
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... meningitis), MCC CNS ... collaboration • CNS ... #management #signs ... #symptoms #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... • Triggers: Diuretics ... WBC >100k, + lab signs ... TLS #diagnosis #management ... #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... #neurology #rheumatology ... cerebritis #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... the study) • Triggers ... ATRA treatment Pathophysiology ... APML #diagnosis #management ... #hematology #oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... vasculitis • Behcet ... syndrome: Recurrent ... chorioretinitis, CNS ... Differential #Diagnosis #Rheumatology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... that results in CNS ... • Bilateral signs ... Neurosarcoidosis - MCTD - Bechet ... Myelitis #diagnosis #management
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
TAFRO TAFRO syndrome ... cell lymphoma Pathophysiology ... histopathologic changes in LNs ... TAFRO #diagnosis #management ... #rheumatology #
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... MC: CNS CSF: • ... Aspergillosis Pathophysiology ... ) #Mycoses #InfectiousDiseases ... Fungal #Diagnosis #Management
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