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C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook

Clinical Presentation + Progression:
C.diff - Clostridioides ... Perforation) Pathophysiology ... Epidemiology: • #1 ... 10 mg/kg IV x 1 ... #infectiousdiseases
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
prostaglandin E2 • Triggered ... Cytokines (IL-1, ... production • Treatment ... Serotonin syndrome • Treatment ... #Hyperthermia #comparison
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
the study) • Triggers ... : ATRA treatment ... Pathophysiology ... symptoms, or> 1 ... Renal Failure Treatment
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
• Prevalence: 1- ... associated with DM-1, ... Person Syndrome Pathophysiology ... tendency to fall • Triggers ... Person Syndrome Treatment
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
resolves after > 1 ... articular cartilage triggers ... #Degenerative #Comparison ... JointPain #Diagnosis #pathophysiology
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles
Note: Some charts show different relative levels of
Ovarian Cycle 1. ... can vary) • Triggered ... Uterine Cycle: 1. ... #OvarianCycle #pathophysiology ... #comparison #endocrinology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
Histoplasmosis Treatment ... clinical forms: 1) ... Mucormycosis Treatment ... Aspergillosis Pathophysiology ... ) #Mycoses #InfectiousDiseases
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
dysfunction. 1. ... recognition and treatment ... search for and treatment ... Pathophysiology ... Treatment Approach
Diets and Inflammatory Bowel Disease (IBD)
Diet affects IBD by 3 mechanisms
1. Microbiome ( ↓ diversity)
2. Mucosal
3 mechanisms 1. ... carbohydrates that may trigger ... IBD #Nutrition #comparison ... table #management #treatment