86 results
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... • Triggers: Diuretics ... - ACS, AKI, acute ... WBC >100k, + lab signs ... TLS #diagnosis #management
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
>10 mmHg - clinically ... significant portal HTN Signs ... and hepatorenal syndrome ... obstruction) • Lack of signs ... • Cirrhosis/acute
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... osmolarity If cause ... investigations depending on clinical ... context and signs ... #causes
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer’s Disease ... Pathogenesis and Clinical ... mutations - Down syndrome ... chromosome 21) Signs ... geriatrics #diagnosis #signs
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... Pathogenesis and clinical ... #diagnosis #pathophysiology ... #signs #symptoms ... #orthopedics #neurology
Approach to Headaches - Differential Diagnosis Algorithm

Red flags (PHANTOMS):
 • Pattern change, progressively worse, papilledema
 •
papilledema • Horner syndrome ... artery tenderness, triggered ... • Meningeal signs ... Systemic symptoms and signs ... arteritis • Acute
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
hypertension and signs ... 109 mm Hg) with clinical ... renal bruit or signs ... Renal parenchymal disease ... Neurologic disorders
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
Pathogenesis and Clinical ... rubbing • Atopic diseases ... > Keratoconus Signs ... Ring • Munson's sign ... • Rizutti's Sign
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
Pathogenesis and Clinical ... other autoimmune diseases ... erythematosus (SLE) Signs ... #Pathophysiology ... #Diagnosis #Signs
Brudzinski’s Sign in Meningitis (first described in 19th century by Dr. Josef Brudzinski)

Brudzinski's sign is characterized
Brudzinski’s Sign ... Passive neck flexion causes ... While the pathophysiology ... despite severe disease ... #Meningitis #Clinical