13 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• recurrent fractures ... Malnutrition • Wilson's disease ... collection with EDTA Pathophysiology ... mineralization Symptoms ... pain - Frequent fractures
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Pott's Disease in ... of active pulmonary ... decreased reflexes Pathophysiology ... of bacilli to bone ... in ALL patients
Fat Embolism Syndrome
Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Trauma to the long bone ... stabilization of fractures ... Pathophysiology ... onset widespread pulmonary ... #Signs #Symptoms
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
Paget’s Disease: ... , kyphosis and fractures ... • Incr serum ALP ... #diagnosis #signs ... #symptoms
COVID-19 - A Seattle Intensivist's One-Page Cheat-Sheet on COVID-19 v2.7 Updated March 26 2020

(v2.7) incorporating newer
Intensivist's One-Page ... matthewarentz et al ... Infection: Coronavirus Disease ... unilateral* • POCUS ... #Cheatsheet #Diagnosis
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
40% of patients diagnosed ... history of the disease ... immunity Signs/Symptoms ... cells in blood and bone ... Agammaglobulinemia #XLinked #pathophysiology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... • Pulmonary infarction ... • COVID-19 Pneumonia ... associated with any symptoms ... #differential #diagnosis
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... -> Pathologic fractures ... PagetsDisease #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
mellitus, thyroid disease ... , humeral head fracture ... inflamed, usually in one ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms
Rickets and Osteomalacia: Pathogenesis and Clinical Findings
 • Calcification inhibitors (excess exposure to A1, Fluoride, etidronate)
enzymes (like ALP ... Bowed legs • Fractures ... #Osteomalacia #pathophysiology ... #diagnosis #signs ... #symptoms