11 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Liver function tests ... hemophagocytosis in the bone ... CD163 staining of bone ... is found in the bone ... #Syndrome #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... accumulation of clinical ... , Biological + Bone ... /ml, ↑ LDH • Bone ... treatment #summary #rheumatology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... swelling of the bone ... • Bone and joint ... : • A clinical ... SAPHO #Syndrome #Rheumatology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
life Causes and clinical ... resolve within one ... Disorientation, vertigo Diagnostic ... Cold #Urticaria #diagnosis ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... Diagnosis via genetic ... Hemophagocytosis in bone ... management #treatment #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
adults in the west ... Orange or Hep C Clinical ... phenomenon CLL Diagnosis ... Warm AIHA • Bone ... lymphoma • Marginal zone
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Clinical suspicion ... Amyloidosis Clinical ... muscle wasting Bone ... Inflammation → Macrophage activation ... : • Diagnostic
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... present variably: On one ... the “Chewing gum test ... positive at least one ... them, but urgent rheumatology
Preoperative Risk Evaluation

Major Pre-Op Questions:
1. Does the patient have any modifiable risk factors that could be
determine if stress test ... Change in clinical ... CPAP if they have one ... HgbA1c - if not done ... stratification #diagnosis
Trigger Finger - Stenosing flexor tendon tenosynovitis

There is a change in the slip between the tendon
classic frame is the one ... The diagnosis is ... clinical, and can ... #physicalexam #orthopedics ... #rheumatology