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diagnosis clinical physicalexam neurology hematology differential ophthalmology half one oneandahalf balint management mds monoclonal myelodysplastic simultagnosia vascular workup acquired alien
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... bleeding, infections, bone ... cells - Blood and Bone ... • Headaches, bone ... neutropenia) • Bone
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Warm AIHA • Bone ... • Richter’s Syndrome ... lymphoma • Marginal zone ... • Sezary syndrome ... diagnosis #workup #oncology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... sustained over a one-hour ... Superior Vena Cava Syndrome ... shoulder pain, collateral ... : Tumor Lysis Syndrome
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... • Bone marrow ... transformation to acute leukemia ... Myelodysplastic #Syndrome ... treatment #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone ... megakaryocytic Bone ... the blood and bone ... blood smear • Bone ... diagnosis #hematology #oncology
Gastric Neuroendocrine Tumor (NET) Types Type 1 - Chronic atrophic gastritis and pernicious anaemia Type 2 - Zollinger
Zollinger Ellison syndrome ... MEN)-1 Type 3 - None ... Classification #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... virus (EBV) • Leukemia ... Hypoplastic MDS: • ↓ bone ... • Suggested by bone ... hypoplasia/fatty bone
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
paraproteinemia, acute leukemia ... alkalosis, Hungry bone ... syndrome, Tumor ... genesis syndrome ... FGF-23: Fanconi syndrome
Simultagnosia on Physical Exam (Balint Syndrome) The patient can recognize objects one at a time but cannot
Physical Exam (Balint Syndrome ... recognize objects one ... Simultagnosia #Balint #Syndrome ... PhysicalExam #clinical #video
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 Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
certain types of leukemia ... skin lesions by one ... Panniculitis - Leukemia ... - Lupus - Leukemia ... #dermatology #oncology
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