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oncology treatment aplastic chronic lymphocytic mds myelodysplastic pathophysiology syndrome workup activation algorithm ascorbicacid bandemia cancer cbc cell classification common cvid
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... blood smear or on bone ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Diagnosis: • ... • Neutropenia, anemia ... Warm AIHA • Bone ... #oncology #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
with hypocellular bone ... Consider stem cell ... to MDS or acute leukemia ... #diagnosis #management ... #treatment #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... • Bone marrow ... transformation to acute leukemia ... Allogeneic stem cell ... #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... immunophenotype Clinical ... 5) Symptoms of anemia ... #oncology #hematology ... #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... Clinical Presentation ... virus (EBV) • Leukemia ... #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Differential Diagnosis ... Tissue damage • Leukemia ... likelihood of negative clinical ... neutrophil #WBC #CBC #hematology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Deficiency) - Diagnosis ... and Management ... Mucous membranes • Bone ... poor nutrition Clinical ... nonimmune hemolysis MSK
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... Low or absent NK cell ... Hemophagocytosis in bone ... #management #treatment ... #hematology
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