7 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... Features: POEMS, AL ... Cryoglobulinemia Renal-centered ... w/ monoclonal gammopathy ... Differential #Diagnosis #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• softening of bones ... of feet, thigh bones ... neuropathy • Renal ... : - Renal failure ... Hyophosphatasia #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Pregnancy - Renal ... disease - Bone ... Diagnosis #Algorithm #hepatology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... Summary Framework Hematologic ... hyperCalcemia, Renal ... MGUS #Monoclonal #Gammopathy ... #Significance #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
of Monoclonal Gammopathy ... osteoclast activity and bone ... resorption - Bone ... ; vaccinations Renal ... Complications #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
or polyclonal gammopathy ... Castleman disease • AL ... cancers, HCC, renal ... gastric tumors • Hematology ... differential #diagnosis #hematology
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
fasting/weight loss RENAL ... and memory loss HEMATOLOGIC ... Osteoporosis - Low bone ... mortality rates of all