13 results
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
Causes of Hyperferritinemia ... be used by the bone ... Renal -15% 6. ... Renal failure - ... Hematologic Malignancy
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... Summary Framework Hematologic ... hyperCalcemia, Renal ... MGUS #Monoclonal #Gammopathy ... #Significance #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... neuropathy • Renal ... : - Renal failure ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... arthritis, monoclonal gammopathy ... syndrome, post-bone ... nephrology #diagnosis #renal
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Highest • Bone ... Intestine - Other causes ... Pregnancy - Renal ... disease - Bone ... Diagnosis #Algorithm #hepatology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
dL the ULN R - Renal ... more: • Clonal bone ... Causes of false- ... amyloidosis Other causes ... MGUS #diagnosis #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
of Monoclonal Gammopathy ... osteoclast activity and bone ... resorption - Bone ... ; vaccinations Renal ... Complications #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Causes of Monoclonal ... Gammopathy Include ... cancers, HCC, renal ... gastric tumors • Hematology ... differential #diagnosis #hematology
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
mutations - BMPR2 (bone ... multifactorial mechanisms Hematologic ... mediastinitis, chronic renal ... #Differential #Causes
Medullary Nephrocalcinosis on Renal POCUS

Female with right flank pain.  Diagnosis and cause?  
Answer: Medullary
Nephrocalcinosis on Renal ... POCUS Female ... Diagnosis and cause ... Robert Jones @RJonesSonoEM ... Nephrocalcinosis #Renal