16 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... stimulation (placenta/Bone ... - Highest • Bone ... Renal disease - Bone ... #hepatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Hyophosphatasia #hepatology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
for bone marrow ... significance (MGUS) A bone ... whom there are no clinical ... #diagnosis #management ... #hematology #multiplemyeloma
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... disease - If ALP ... : Bone, first trimester ... differential #diagnosis #algorithm ... #hepatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... /or suspicious clinical ... ALP, alkaline phosphatase ... LFTs #Abnormal #Algorithm ... #Hepatology #Liver
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
Get an LP and imaging ... Returning Traveler’ algorithm ... node biopsy • Clinical ... values supporting hematologic ... Bone marrow biopsy
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
= Hypocellular bone ... Hypoplastic MDS: • ↓ bone ... • Suggested by bone ... hypoplasia/fatty bone ... Anemia #oncology #hematology
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
Diagnosis and Management ... Hypercellular bone ... • Treatment algorithms ... PV #Diagnosis #Management ... Summary #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... , Biological + Bone ... Assessment • Clinical ... /ml, ↑ LDH • Bone ... Lymphohistiocytosis #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
hemophagocytosis in the bone ... CD163 staining of bone ... is found in the bone ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology