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diagnosis hematology management oncology differential rheumatology amyloid amyloidosis clinical encephalopathy gammopathies hemeonc hemophagocytic hlh joint knee leukemia lymphohistiocytosis mds mgus
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Generally affects long bones ... • XR, MRI to ... BrighamChiefs #Bone ... #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... Rule out other causes ... - MRI: inflammation ... osteoarticular and skin disease ... diagnosis #management #Dermatology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
g/dl LLN B - Bony ... more: • Clonal bone ... focal lesions on MRI ... Causes of false- ... plasmacytoma, POEMs syndrome
Osgood-Schlatter Disease - MSK Radiology Imaging Findings: • Infrapatellar fat-pad edema with loss of the patellar tendon
fragmentation and mild bone ... possible secondary ossification ... • MRI is more sensitive ... marrow edema and bony ... patella #clinical #mri
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Drug induced - Bone ... marrow disease ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... #nonpalpable #dermatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone ... megakaryocytic Bone ... Aplastic Anemia • Bone ... blood cells in the bone ... blood smear • Bone
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... bleeding, infections, bone ... cells - Blood and Bone ... • Headaches, bone ... neutropenia) • Bone
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Shock, Autoimmune disease ... Transplantation including bone ... Vascular narrowing on MRA ... the underlying cause ... with AEDs until cause
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
the extent of disease ... : • Nephrotic syndrome ... muscle wasting Bone ... Carpal tunnel syndrome ... enlargement • MRI
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... caused by uncontrolled ... ▪ Autoimmune diseases ... Hemophagocytosis in bone ... Diagnosis #Management #Hematology
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