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management hemophagocytic hlh lymphohistiocytosis anemia aplastic febrile infant lp pediatrics rheumatology risk stepbystep stratification ebm hemeonc oncology summary tafro thrombocytopenia
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Symptomatic anemia Diagnosis ... with hypocellular bone ... (transfusions, antibiotics ... if neutropenic fever ... #hematology
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... an infant with fever ... CRP < 20 mg/L #Diagnosis ... Management #Pediatrics #Peds ... #LP #Antibiotics
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
following: • Fever ... Hemophagocytosis in bone ... • Bicytopenia Treatment ... rapidly, and empiric antibiotic ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... - β-lactam antibiotics ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... , Biological + Bone ... • Clinical: fever ... /ml, ↑ LDH • Bone ... #management #treatment
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
treatment. http ... 92.0% and 46.9% #Diagnosis ... Management #Pediatrics #Peds ... #LP #Antibiotics ... Stratification #Fever
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Pathophysiology ... Fever b. ... Hemophagocytosis in bone ... Treatment Approach ... #Management #Hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
- Anasarca - Fever ... disease, severe fever ... cell lymphoma Pathophysiology ... interfollicular zone ... Hypoalbuminemia Treatment
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