26 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... Most cases diagnosed ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
excessive bone ... turnover -> Incr bone ... Nerve Palsies • Disordered ... PagetsDisease #pathophysiology ... #diagnosis #signs
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... - Differential Diagnosis ... (CVID, WAS), (neurologic ... candidate) - Bone ... #Differential #Diagnosis
Causes of Dizziness - Vertigo - Differential Diagnosis Algorithm
True Vertigo - Illusion of Rotary Movement
Peripheral Vestibular
- Differential Diagnosis ... Media • Temporal Bone ... Dysfunction - Imbalance, neurologic ... Dizziness #Vertigo #Neurology ... #Differential #Diagnosis
Localizing Extraocular Movement Disorders
 • CN Ill (Oculomotor) Nerve Palsy 
 • CN IV (Trochlear) Nerve
Extraocular Movement Disorders ... MLF) Iniury • One-and-a-half ... Skew Deviation Casey ... ophthalmology #neurology ... #differential #diagnosis
Hypophosphatemia - Differential Diagnosis Algorithm
 • Decreased intake/absorption: Starvation, Alcoholism, Malabsorption, Phosphate binder use
 • Redistribution/
- Differential Diagnosis ... malabsorption), Hungry bone ... #Differential #Diagnosis ... #Algorithm #causes ... #nephrology #phosphate
Causes of Hypomagnesemia
 • Redistribution: IV glucose, Correction of diabetic ketoacidosis, IV hyperalimentation, Refeeding after starvation,
Postparathyroidectomy (hungry bone ... metastasis (hungry bone ... ) • Endocrine disorders ... #differential #diagnosis ... #nephrology #magnesium
Hypocalcemia Workup - Differential Diagnosis Algorithm
 • Low Magnesium, High Magnesium - Functional Hypoparathyroidism
 • High
- Differential Diagnosis ... , Infiltrative disorders ... metastases, Hungry bone ... #Differential #Diagnosis ... #Algorithm #nephrology
Acquired Disorders of Reduced Bone Strength: Pathogenesis
 • Hyperparathyroidism
 • Vitamin D deficiency
 • Malabsorption syndromes
of Reduced Bone ... Diabetes • Other causes ... of bone mineralization ... #BoneStrength #pathophysiology ... #differential #diagnosis
Pisa Syndrome (pleurothotonus) on Physical Exam
A tonic flexion of the trunk of the body to one
of the body to one ... Caused commonly ... neurodegenerative disorders ... Pathophysiology: ... PhysicalExam #clinical #neurology