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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Thrombotic Microangiopathies ... Lupusreference #TMAs #Thrombotic ... Erythematosus #SLE #hematology ... differential #diagnosis ... #causes
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes of Arterial ... - Differential ... artery aneurysm: Causes ... APLS:PLT ↓ HEMATOLOGIC ... #Differential #
“H’s & T’s“ - The reversible causes of Cardiac Arrest 
Hypovolemia, Hypoxia/Hypoxemia, Hydrogen Ion Excess (Acidosis),
The reversible causes ... Pneumothorax, Thrombosis ... (Pulmonary), Thrombosis ... #HsTs #acls #differential ... diagnosis #arrest #management
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... • Differentiate ... SickleCell #Disease #differential ... #diagnosis #causes ... #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
- Differential ... considered in all cases ... coagulation and other causes ... pathophysiology #hematology ... #differential #
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Causes of Ascites ... - Differential ... • Portal vein thrombosis ... • Splenic vein thrombosis ... #causes
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Approach to Thrombotic ... Microangiopathy (TMA) - Differential ... Diagnosis and Management ... #Diagnosis #Management ... #Algorithm #hematology
Causes of Breakthrough/Extension of Thrombosis and Management Algorithm

#Anticoagulation #Breakthrough #Thrombosis #Algorithm #Extension #VTE #DVT #Hematology #Management
Causes of Breakthrough ... and Management ... Extension #VTE #DVT #Hematology ... #Differential # ... Causes
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... candidate) - Bone ... or if a primary hematologic ... Platelet #Disorders #Differential ... #Workup #hematology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Algorithm and Causes ... hyperplasia of bone ... Anemia #Algorithm #Differential ... #Causes #Workup ... #Hematology #Diagnosis