49 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... in Sickle Cell Disease ... • XR, MRI to ... Pain #SickleCell #Disease ... differential #diagnosis #causes
Osgood-Schlatter Disease - MSK Radiology
Imaging Findings:
 • Infrapatellar fat-pad edema with loss of the patellar tendon
- MSK Radiology ... fragmentation and mild bone ... • MRI is more sensitive ... patella #clinical #mri ... Radiology #diagnosis #msk
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Tumours - See Bone ... Scheme Paget's Disease ... • Bone Marrow ... Fractures #Pathologic #MSK ... #Orthopedics #Causes
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
ULN R - Renal disease ... more: • Clonal bone ... focal lesions on MRI ... Causes of false- ... amyloidosis Other causes
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... damage weakens the bone ... Femur #Fractures #msk ... #differential #causes ... #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... Complications #pathophysiology
Gout (Gouty Arthritis) - MSK Radiology
Imaging Findings:
 • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
Gouty Arthritis) - MSK ... Case description ... - **MSK rads ... diffuse chondral disease ... Radiology #diagnosis #msk
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... • softening of bones ... Malnutrition • Wilson's disease ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... Abnormal Osteoclasts cause ... formation MSK ... causes middle ear ... PagetsDisease #pathophysiology
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Pott's Disease in ... extrapulmonary cases ... decreased reflexes Pathophysiology ... of bacilli to bone ... Diagnosis: - MRI